This William born 1807 and Edley (his brother?) have always been a loose end for me. I propose they are sons of Josiah (ca. 1765-1830), brother of Lt. William. What do you think?
1850 Western Dist., Tazewell, VA William McGuire 43 male farmer born VA Polly McGuire 47 fem born VA Rachel McGuire 40 fem born VA
1850 Western Dist., Tazewell, VA Edley McGuire 50(should be 40?) male farmer born VA Josia McGuire 19 male farmer born VA (named after grandfather?) Betsy McGuire 18 fem born VA (named after mother Elizabeth?) Nancy McGuire 5 fem born TN Polly McGuire 2 fem born VA
1860 Baptist Valley, Western District, Tazewell, VA William McGuire 53 male farmer born VA Polly McGuire 58 fem born VA Edley McGuire 51 male farmer born VA Nancy McGuire 14 fem born TN Rachel McGuire 51 fem born VA Alex Beavers 18 male farm laborer born VA
For what its worth: Bird Brewster was living next to Edley in 1850.