The name comes from the town of Meisenheim on the river Glan. It is in the Hunsruck part of the Pflaz. about 55 miles west of Frankfurt. A Meisenheimer is a person from the township of Meisenheim. The name appeared sometime after 1605 in the village of Waldalgsheim. This was the father of Nicholas Meisenheimer from whom all Meisenheimers are descended. I discovered this on my trip to Deutschland in Sept 99. Herr Schramm of Waldalgsheim has done a lot of research about the family and has quite a descendant list, and says all of us can be traced back to Nicholas.