I am not researching this family, but have just been reading a genealogy which includes information on them.From "Virginia Kaleidoscope" by Margaret Claytor Woodbury & Ruth Claytor Marsh:
"Samuel was the first Mothershead recorded in Virginia, but of no determined relationship to our ancestor, John Mothershead.He was the immigrant ancestor of Ann Mothershead who married Thomas Claytor, son of the immigrant Thomas Claytor."
"By his disposition in 1707, in Westmoreland County, Virginia, John Mothershead states his age as 46 years ofld, indicating birth about 1661....John's desposition was signed by his mark.Samuel by contrast, could read, write, and cipher and was suspected to be of aristocratic origin.... John Mothershead was indentured to Thomas Pope, a relative (probably son) of Nathaniel Pope who hired Samuel Mothershead as tutor."
"John Mothershead was closely connected to the Quesenberry's, as the northern neck and later Floyd County, Virginia branches spelled their names, and it is theorized that his wife Elizabeth was from this family. Elizabeth's mother was Anne Pope, sister of Humphrey."
On another page "Anne Pope, was thought to be a cousin of the Anne Pope (daughter of Nathaniel) who married Col. John Washington of Wakefield."
In another chapter - "John Mothershead came to Virginia as an indentured servant around 1675, and was free around 1682.John's 'freedom' did not come easily."
"The Claytors, Butlers, Qui(e)senberrys, Popes and Mothersheads lived in the same area (of Virginia).