Somebody mentioned that they'd traced the American MOTTERSHEDs (whatever spelling you choose :) to a single individual who arrived in VA in the 1600s. This has been the "received wisdom" among MOTTERSHED researchers for quite a number of years, it is incorrect. Generally, they have labeled Samuel MOTTERSHED (arrived in VA 1652, sent by Nicholas HAYWARD, a London Grocer) as the founder, though some have tried to make it Zachary MOTTERSHED (in Calvert's service, died c1640). As nice as it would be to have a single identifiable person, this can be proven to be incorrect.
To dispense with Zachary first, there is no indication that he had a family at all. The inventory of his estate exists, and clearly indicates a literate man of modest means (though not poor) living alone, probably in a single room. That's sensible: he was Calvert's man, and if he had no family it's very likely he would live in Calvert's household. Also, since he was Calvert's man, he is almost without doubt Catholic. There is a record of Zachary performing a fairly significant service for Calvert. It is almost unthinkable that Calvert would have had non-Catholic employees at all, much less one in a position of any importance.
As for Samuel, he arrived in VA in 1652 at the age of 22 (proof exists). In 1658, when Samuel is 28, he appoints an attorney to represent him in a civil suit; a Jonathan MOTTERSHED signs as a witness to that appointment (proof exists). We aren't yet certain who this Jonathan is, but he would have been at least 18 and probably over 21.
We can't yet prove who Samuel's parents were, though it's possible that he's the Samuel MOTTERSHED whose birth or christening is recorded in Cheshire, England 20 Jun 1630 (MOTTERSHED is a basically Cheshire name, though by the 1600s you can find them scattered all over). This possibility is based on the family of Thomas MOTTERSHED of the Cheshire whose wife is Sarah LINGLEY/LANGLEY, with children Samuel (20Jun1630), Thomas (29May1632), Elizabeth (28May1633), Albion [sic - probably later Alvin] (08Jul1635), Mary (22Mar1640), Jonathan (05Dec1640), Nathaniel (05Apr1643), Sara (14Feb1646). The marriage and birth records were originally recorded Holy Trinity Church, Chester, Cheshire, England, and are still available. Also, a 'John' (1634) and two 'Sara's (1637, 1644) were recorded; presumably they died in infancy. Also, Thomas was a royalist (proof exists), Church of England, a merchant and of fairly high status (he was a mayor of Cheshire). Thus, he's a good candidate for a business associate of Nicholas HAYWARD. Also, a Margaret MOTTERSHEDDE marries Thomas HEYWARD in Cheshire on 30 Mar 1600, which could provide the family connection that one generally expects in 17th century business matters.
Anyway, what's clear is that Samuel is not the only adult MOTTERSHED in VA c1652-1665 (there are still others beyond the Jonathan listed above). Actually, we have yet to see any proof that Samuel was ever married and had children. People claim he married Elizabeth POPE, but nobody claims to have a source document that supports that; nor have we ever seen anybody claim to have a will for Samuel. And it's very clear that there is a vast amount of confusion of people because of continued reuse of given names. For example, we've seen it claimed that the Nathaniel who is a RevWar veteran is also the Nathaniel who was born in 1709 (or, according to some, 1698), which is patently ridiculous. We've also not seen proof that Nathaniel who's born 1709 is the same Nathaniel who married Mary MINOR in 1761 and died in 1781 and had seven or eight kids in between (which isn't completely ludicrous, but seems highly unlikely).