I posted what I found in the order I found it, which is why I was guessing "Gimmoz" for Sophrana's maiden name at first. You'll see what I was looking at on the WV Heritage site when you re-trace my search.
http://www.tedpack.orghttp://www.tedpack.org has a genealogy section. The three pages that may interest you are the ones about posting a good query, finding people in the LDS 1880, and, if you have (or get) an ancestry subscription, the one titled "Those Elusive Edes", which has some hints for finding people in the Ancestry census images. There is also "Which Ted am I", which has my picture.
These people may be related to yours; they may not. Note the Gunnoes and Medleys are on pages 132A and B in 1850, which means John and Cora could hook up without John having to ride too far. Cora either isn't there is, is using a different name, or this is a collateral line.
1860; Census Place:, Kanawha, Virginia; RollM653_1356; Page: 230; Image: 237; Family History Library Film: 805356.
Hulda Medley 66 John A Medley 26 Richard Walker 15
1850; Census Place: District 29, Kanawha, Virginia; RollM432_954; Page: 132A; Image: 267.
John Medley 60 Jane Medley 57 Matilda Medley 30 Alethia Medley 23 Franklin Medley 20 Margarett Medley 17 Martha Medley 15 John Medley 14 Joseph Medley 12 Elizabeth Medley 11 James Medley 9
1850; Census Place: District 29, Kanawha, Virginia; RollM432_954; Page: 132B; Image: 268.
John Gunnow 58 Margaret Gunnow 40 Mary Gunnow 18 Priscilla Gunnow 15 Sarah J Gunnow 13 John Gunnow 4 George Gunnow 10 William Gunnow 7 Julia Gunnow 9 Isaac Gunnow 18