My research on Grubbs has been mostly in SC to Miss, mainly in North MS.My only Grubbs link that I know of is in Barbour Co. where William Grubbs settled.He was oldest son of Enoch Grubbs, Sr. by his first wife.
I have some old notes, so old I am not sure where I got them, of three Grubbs in Blount Co. around 1829 named Thomas, Enoch, and Isaac.
In 1860 US Census 1 Subdivision Blountsville page 902 is listed Isaac Grubs 65 born SC, Nancy 54, Lucinda 19, Louisa 15, Manerva 13. On the same page is Jackson Pannell 22, Matilda 23, Lodusca 4/12, William Ellis Pannell 54, Rebecca 52, Adaline 19, Gideon 17, Harriet 15, Epse?female 13, Martha 11.
In 1870 Blount Springs page 407a house #7 is Isaac Grubbs 75, Louisa 46, Manerva 22.
House #8 is Lucinda Grubbs 30, Lemuel 11, Sarah 6, and Lucinda 3. If Lemuel was really 11 he should appear somewhere in 1860.
Isaac is not a son of Enoch Sr. of SC, but some of the names I've mentioned are commonly used in his family so there may be a connection.Not much is known of Enoch Sr.'s background.
You may have this Census dataalready.I can't say what significance it has and because in these early records they did not give family relationships the 1870 does not tell us who the children are.But they must have been connected in some way to Isaac Grubbs.
I have a lot of Pannell names in AL as well as other places, don't know who they are.It appeared that they came in from different places, unlike those in North MS most of whom were from SC.Byars is not a name I am familiar with.