I have some information which I got from various London Directories which will be useful to you. In Piggot's 1827 Dr George Pearse is living at 46 Marsham Street, Westminster and his office is at 5 Regent Street.There is another Dr. Pearse living on Dean Street and with office on Commercial rd. In Piggot's 1836, Dr George is still at the same locations but John Pearse is also listed as a Surgeon at 5 Regent St. Dr. Charles Pearse is a Surgeon at 37 Regent Street and lives at 37 Roebuck St. Dr. David Wiiliam Pearse is a Surgeon on Commercial Road and lives at 20 Colet Place. In Thompson's 1844,Dr George is living on Marsham St. and is listed asa Surgeon and Registrar.Dr. Samuel Pearse is a Surgeon at 135 bethnal Green Rd.David W. still at Colet place. In WAtkin's 1852 George Pearse is a Surgeon at 10 Regent Street. Edmund Pearse is a Surgeon at 7 Argylle Square, Kensington. W. E. Grindley Pearse is a Surgeon and Registrar at Horseferry Rd. and lives at 46 Marsham ST.
If George died in 1846 ,it appears that he had a son George who carried on for his father, living in his father's house on Marsham St. I dont know that my own family of Pearses, who were active in the Wool, clothing and Insurance business in the City at that time are related to yours. I have no indication of it. If you have any info. on George's family, please let me know.