**Obituary -- Senora Maria Isabel COTA de PICO, whose death at this place we announced last week, was a lady whose great age, extensive acquaintance with our earliest pioneers, and relationship to many of the most prominent families of the State, make her demise an occurrence of more than usual interest, and worthy of more than passing notice. She was born at Santa Barbara, in this State, on the 28th day of May, 1783. At the age of 19, she intermarried with Jose Dolores PICO, one of the 3 brothers, Jose Maria PICO, Patricio PICO and Jose Dolores, who came to California with the first Mexican colony, as officers in the military service of the Spanish Vice Royalty of Mexico. Jose Dolores was active and very efficient in founding the Missions, and coping with and civilizing the Indian tribes, then powerful in the southern portion of the State. He died in 1827, having given 50 years of military services to his country -- first, under the Government of Spain, and then under that of Independent Mexico. The children born of this marriage were 13 in number. They, with their cousins, children of their father’s brothers, and their allies by marriage, the CASTRO’s; were all powerful in the Governmental affairs of California, up to, and at the time of the American invasion. One of the sons was Antonio Maria PICO, who died at San Jose last May, having filled several high offices, both before and since the conquest. Senora PICO’s descendants number over 300, one being of the 6th generation; nearly all living in this State, bearing the names of the most prominent Native Californian families -- and many of them, those of some of our leading American citizens, who have married members of these families. One of her grandsons is Capt. PICO, of San Jose, who commanded a cavalry company in the service of our country during the late civil war. Full of years, and surrounded by many affectionate descendants, she has joined “The innumerable caravan that moves To the pale realms of shade.”And a wide void is made among those whose existence connect the toiling, driving, grasping Present of California, with its calm, easy, contented, and many of our oldest settlers think, better and golden Past.