The more research that I do, the more I seem to focus on the idea that Jacob Purkypile of Crawford (Jackson Twp), Ohio and married to Rebecca Edwards, might have been a brother of Jesse Purkeypile and sister Margaret.
The fact that they all end up living in Crawford County Ohio seems to be more than a coincidence. Keep in mind that families back then tended to be BIG so it seems likely that Andrew would have had more than two children.
The existence of another Jacob Purkeypile, age 63 at the time of the 1850 census, living next door to other Purkeypiles, also suggests a connection. So here is my working theory (subject to fact checking):
Andrew Purkeypile (b. 1754 d. 1840) - married to "Jane"*
Their sonmight be Jacob Sr. born in 1787 (1850-63 years of age) Jacob Sr. marries "Margaret"
Is it possble that Margaret (b. 1801), Jesse (b. 1804) and Jacob Jr. (b.1810) are all the offspring of Jacob Sr.?
Footnote (*): I have found two land deeds from York county that might shed light on this group;
(1) in 1805 Jacob (Sr?) buy land in Hopewell Twp, York Co. from David Gorsuch for $4,318 (about 380 acres).
(2) in 1831 Jacob (Sr or Jr?) buys land from "Andrew & wife Jane" in Hopewell Twp, York Co. The deed document indicates though that Jacob Perkepile resided in Lancaster County.If Andrew bought land in Ohio in 1831 (coincidence?), perhaps he used the proceeds from the sale of his Hopewell Twp property to Jacob (Sr or Jr)
(3) a book about the history Lancaster County has two mentions of Jacob Purkeypile. First he and his wife are members of the Presbyterian church in Columbia borough in Lancaster from 1808 to 1822. This would have to be Jacob Sr as Jacob Jr hasn't been born yet. The second mention indicates that a Jacob Purkeypile was an investor in the Columbia, Pennsylvania Book Company (a library) that was founded in 1829 and dissolved four years later (in 1833). This might be Jacob Sr
(4) a Jacob Purkeypile is recorded as a juror in York County in 1837 and his age is listed as "about 37", indicating a birth date of 1800. This might be Jacob Jr. My gggrandfather Jacob was still living in York County through the mid 1840s, as the 1850 census lists three children being born in Pennsylvania and their ages place their birth dates in the late 1830 and early 1840s. My Jacob Jr marries Eliza Grosh in 1829 and she dies in 1831. He remarries to Rebecca Edwards in 1831.
My theory is that Jacob Jr leaves York circa 1843-44 and moves to Crawford County with the rest of the Purkeypiles. He and wife Rebecca had 12 children, including my ggrandfather Francis Levi (b. 1848 in Ohio).
+++++++++++++++++++++++ I don't have enough documentation to link all of these Purkeypiles together. The key would be to find a birth notice for Jesse and/or Jacob so that we can find out who their parents are. That would be our Rosetta Stone.
If anyone has any documentation on Jesse, Jacob and Margaret then please step forward and share it with us.