Now those are some good clues!
From the 1880 census for Lawrenceburg, Dearborn County, Indiana is the 'Andy Pusey' household:
Andy Pusey, 60, Millwright, born in Maryland, both parents born in Maryland
Mary M. Pusey, 56, wife, born in Germany, both parents born in Germany
Henry Pusey, 30, son, Millwright, born in Indiana
Mary Pusey, 22, daughter, born in Indiana
Andrew J. Pusey, 20, son, Millwright, born in Indiana
Martha Pusey, 18, daughter, born in Indiana
Elizabeth Pusey, 15, daughter, born in Indiana
Based on the Emma Freeman 1880 census listing and what you said about her sister 'Lizzie' and father Andrew, I'd say this is the right family!Now the question is, who were Andy's parents.There were a few of the Chester County Puseys who migrated to/through Maryland in the 1700's, one of whom was George Pusey (grandson of William Pusey and Elizabeth Bowater through their son John and his wife Katherine Maris).
George Pusey was born 1742/3 and married Sarah Cox.They moved from Chester County to live in Harford, Baltimore, and Frederick counties in Maryland sometime around the Revolution and all of their children.They had 4 sons: William, Joel, Nathan, and George (and 3 daughters, Lydia, Mary, and Mercy).The Joel Pusey line is pretty well documented.Some of his children, and many of his sisters' children, were living in the midwest (Ohio, Indiana, Illinois, Minnesota, Iowa, Kansas, Missouri) by the end of the 19th century.Of the four sons, I have no lineage for three: William, Nathan, and George.It may be that they died young, unmarried, or without issue.Or just that no one has bothered to trace their progeny (hint-hint).
Another possibility is that Andrew Pusey is a descendant of the Eastern Shore Puseys from Worcester County, Maryland.I am not as familiar with this family but the era and state of birth would make this a reasonable lead to follow.