Distantly, if at all. The McGuire researchers are in the process of using DNA to sort out some of the early Virginia McGuires. My McGuires were in Greenbrier, VA as early as 1769 (maybe earlier)and may be realted to the McGuires in Tazewell. I am more directly related to the Quicksalls. My gggg grandfather was James Quicksall, brother to Aaron and Elizabeth.