Hi, Michelle. I am also descended from William Hood and Margaret Renfroe. i would love to exchange information. You seem to have more than I do (I did not know the names of William's siblings, nor do i have his parents' names.) I also have no more information on Margaret than her maiden name.
Here is what I have so far (I have just recently started researching this line, so please let me know if you see any mistakes):
William Hood (b. 1812). Probably died between 1850 and 1870, as he is in 1850 census, but not enumerated with family in 1870.) married Margaret b. 1822 (Possibly Renfroe?), prob. married before 1843. Both were born in GA, according to census. They are in Hancock Co. by 1850, I haven't found them in 1860 census, and Margaret is listed as head of household by 1870 (in Hancock.)
Children: John M. Hood (b. 1843) - Confederate Veteran Elizabeth Hood (b. 1844) David C. Hood (c. 1847) Thomas Hood (1849) Sarah Patience Hood (my gggrandmother) (b. 7 sept 1851 - d. 24 dec 1931) m. John Thomas Knowles Martha A. Hood (c. 1854) Charles Hood (c. 1859)