Hello Leigh: As far as I know, no one has proven a surname for the Nancy "Ann" who married William SALE born 1720/25 and died 20 Oct 1788.This could well be one in the same William and Ann. That is the William who is son of William and Hannah SALE, son of Cornelius and Mary Samuel SALE, son of William SALE, the immigrant.
Here are names listed in William's WILL of Wilkes Co NC.
1787 Will of William Sale shows wife Ann and children, Cornelius, William, James,Robert, Leonard, John, Thomas,Elizabeth, Frances, Molly Martin, Patty Allen, Sally Robards and Peggy Grant. source: JMartin Family list of Wills.
Wiliam's son Cornelius was born around 1750-53, so with the marriage record you have this could be the same one. The daughter listed as Patty ALLEN could well be the Martha you speak of.Patty and Patsy were common nicknames for Martha.