Sorry, no, I wouldn't know anything about Schweisguths in the USA. My immigrant great-grandmother, Maria Felizitas Schuck née Sattel of Schifferstadt, who settled in St. Louis, MO, was the great-granddaughter of Maria Eva Keßler née Schweisguth of Schifferstadt. Her father was Joh. Michael Schweisguth originally of Herxheim who married Maria Apollonia Krämer, a native Schifferstadter. His parents were Joh. Martin Schweisbuth and Anna Clara Rami. Now, as to which Herxheim Schweisguth hailed from I can't say as of this time; one is located at a relatively considerable distance to the southwest of Mannheim near Alsace and Baden, whereas the other, Herxheim-am-Berg, is not too far removed from Mannheim to the northwest. As for myself, I'm in L.A., CA.
Hoping that at least some of the above may be helpful to your research.