Keith...I'm curious to know if the wife of your Jacob Sisler was perhaps Sarah Casteel/Sisler.
Our connections are from John Sisler who md. Tabitha Birch/Sisler abt. 1830 in Preston Co.They had a Thomas who was killed in Hanging Rock, KY sometime before 24 Sept 1856.That was the date that his widow married Jacob Myers.
Please contact me directly if you think these names are included in your lineage.