I have seen Isaac and John listed as brothers, sons of James who was born in Fallsington 1700. John moved to Caswell NC where he died in 1798. The marriage was 1727. So there could be a few children. I havent looked at the Quaker records yet but I have heard that John was a Quaker. His daughter Elizabeth (Betsy) married my 4th great grandfather. I have her birth year as about 1772-4. she died before the 1850 census so we dont know exactly. Plus there isnt a marriage record but the oldest child was born in Tn about 1795. He also died before 1850, likely in the Mexican-American war.