James and Mary Skiff were the parents of five sons and six daughters.
James Skiff, Jr. born 1638, married Sarah Barnard. 6 children Steven Skiff, born 1641, married Lydia Smith, had 6 children. Nathaniel Skiff, b. abt. 1644, married Ruth West, 9 children. Sarah Skiff, b. 1646, married Thomas Mayhew, 7 children. Bathsheba Skiff, b. 1648, m. Shearjashub Bourne, 6 children. Mary Skiff, b. abt. 1649, m. Matthew Mayhew, 5 children. Miriam Skiff, b. 1652 at Sandwich, Barnstable, MA. Patience Skiff. b. 1653, m. Elisha Bourne, 8 children. Benjamin Skiff, b. 1655, m. Hannah Merry. Elizabeth Skiff, b. Abt. 1660, died 1676. Nathan Skiff, b. 1658, m. Hepsebah Codman, 8 children.