She was the dau. of Henry M. Spain and Eliz. Stith
Henry M. Spain was a son of Joel Spain and Jemimah Hastin
from ancestry.com I have found
Joel Spain b. abt. 1765 d.June 21, 1813 in Mecklenburg,VA Wife Jemimah Hasin was dau of Henry Hasting and Agnes"Aggy"
children of Joel and Jemimah were
Henry M. Spainm. Eliz. S. Stith april 10, 1833 Royal Spain b. 1788 James Spain b. 1790 d. Tenn. John Spain b. 1792 m. Martha Coleman in Va Nevil G.Spain b. 1796 Tenn m. Martha B.Hall Louisa Spain b. 1798 m. John Vaughn 1823 Wiley Spain b. abt. 1799 Nathan Spain Mary" Polly" Spain b. abt. 1804 m. Daniel Graves