Elaine, my Spain was from Nenagh. She and her husband, John Cahalan (later Callahan), married at Notre Dame Cathedral, Ottawa in July 1847. (I finally found this record in the Drouin collection on ancestry.com.) They later settled in Litchfield Co., CT though I haven't yet traced their route. One of the witnesses recorded in the marriage register was Elizabeth Spain. I haven't yet determined how they were related. The parents' names were not listed in the marriage record.
Does this fit with any of your knowledge of Spains from Tipperary?