I think that I may have found her in 1880:
1880 Census Cocke Co., TN, Lower Cosby, 10th Civic Dist., ED# 66, Page 440, HH# 125:
Caroline Large, 38, Wd, TN/TN/TN
Mary Jane, 8, TN
Alice, 4, TN
Margaret Spurgeon, 40, Wd, TN/TN/TN
I have not done anything with Caroline or Large families to see if this is my Margaret.In 1860, Margaret should have had James Taylor Spurgeon and his brother John in the household with her, about age 5 and 2.I have not found anyone meeting that criteria yet.James married in 1872, and it may be that his brothers moved into MO about that time also.I did find a marriage for a John Spurgeon and a Sarah Fine in 1883 in Cocke Co., TN, so they may have moved to MO later.James and his wife moved into Jackson Co., Al by 1880.
This may be Margaret also in the household of her son Thomas in 1900:
1900 Census Wayne Co., MO, Cedar Creek Township, ED# 151, Page 40B, HH# 113:
Thomas Spergeon, Nov 1865, 35, Married 6 years, TN/TN/TN
Mary J., May 1873, 22, 2 Children/2 Living, MO/MO/MO
Margaret, daughter, Apr 1895, 5, MO/MO/MO
Lucy, Daughter,Apr 1898, 2, Mo/MO/MO
Margaret, Mother, Sept 1834, 65, Wd, 1 Child/1Living, TN/TN/TN
I don't know that this is the correct family.But I do know that the Webbs and Odells that moved into MO were related to the wife of James, so they may have moved to MO where there were people that they already knew.I don't remember when the Webbs and Odells migrated to MO, tho, so this may just be co-incidence.I also don't know what happened to Miranda, the daughter listed in the 1870 census with Margaret.I don't find her anywhere.And there is no oral famioy history of James having a sister, so she may have died early.
I have a pic of James Taylor Spurgeon at my FTM homepage.I have noticed that the Spurgeon genes show up in the desc., so you may want to look at the pic.The URL is:
Did your Margaret have any sons in the household with her when she was in the household of her parents in 1860?
My email address is firstname.lastname@example.org