It is possible that they had an additional daughter Anna C. Tiffany who was born in 1849. Saphronia died in 1849 and is buried Stow Cemetery, Stow Twp., Summit County, Ohio. I believe George went to California for the Gold Rush and was on the 1850 census in a mining camp:
George was back in Ohio by 1852 and married his second wife, Lucy Dunbar, Saphronia's sister, on January 20, 1853, Summit Co., Ohio.(Summit Co., Ohio, Marriage records, v. B (returns) 1849-1865 Marriage records,FHL US/CAN Film 900961).