I don't have anything on the Tissues before Issac. But I do have a little information on the Tissues from Issac down. Howard, Issac's son married my G.grandmothers sister. And also my grand-fathers brother married into the Tissue family. I have meet the children of this union and know a little about their where abouts. I'm not sure if any of this information would be of interest to you, let me know if you would like to have it.I just found out about this connection myself this last year, so I am kind of interested to know about also.