According to a "professional" genealogist on rootsweb, this John b ca 1817 is the son of David Titsworth (and his first wife Fnu Lnu???) b. ca 1797/99, son of Isaac (who died in 1832 in Crawford Co)I don't know where this John Titsworth is in 1850.He would have been about 33 and had 2 children (possibly twins)The David, John and Spear who are in Franklin co in 1850 are all sons of Isaac.(Dad and uncles to the 1817 one you asked about)
According to source above his wife's name is Mary Ann (Johnson) and kids are Lucy M b 1845 (only one that doesn't match 1850 initials, John Speer, Mary Elizabeth, Daniel R "Danny", Elvira S, Matthew C, Narcissa and Newton C.
Sarah Tittsworth (I didn't forget about Ben--still working on it---will post soon)