Here's what I have on the Totherow's.
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John Totherow, Sr. (est. birthdate 1725). Spouse unknown.
John Totherow, Jr., b. abt. 175?, married Lizzie Clemmer, his 1st cousin and daughter of Margaretha and Felty Clemmer.
Margaretha (Elizabeth) Dettro, b. abt. 1755, married 1) George Valentine (Felty) Clemmer and 2) William M. Hancock
Possible 3rd child or perhaps son of John above:
Jonathan Totherow, b. abt 1776, married Louisa Clemmer, daughter of John Clemmer and Hannah Hoffman.