I have some info that may be helpful and, hopefully, reasonably accurate. Isham may have had a middle name, Berry, hence, his son "Littleberry".Isham was married to Maryann Carter in c.1745.His father was Jacob,born 1695, Eliz. City, VA, died August 7, 1757, Eliz. City. Jacob was married to Courtenay Tucker of VA. Jacob's father was George, born 1659, Areley Kings, Worcestershire, En, died 1732, Kirketan, VA. George's father was Rev. Capt. A. Walker, born 1616, Monkegy, Scotland, died 1675, Williamsburg, VA.