Were any of the Walkup's you are talking about in OHIO??? Specifically, Lima or St. Mary's?
I have an old photo of my grandmother playing in a playground and one of the little girls is listd on the back as Louise Walkup..this would have been about 1916 or so.The reason your posting caught my attention was 1) the Louise family name and 2) Henry and Thomas being doctors....my grandmother's side came from a long line of doctors that practiced in Lima, OH.
You can reach me at email@example.com Look forward to hearing from you. Rene