I do believe Gov Alexander Spotswood had Spanish Blood. In any event, it's the Meade Cromwell family and their connection to the Spotswoods and Washingtons that you really need to look at.
Bishop Meade in his own works claims to be related to both Oliver and Thomas Cromwell.It's Thomas Cromwell and his involvment with Ferdinand and Isabella's Spanish daughter Catherine that is of most interest. Of course she married King Henry VIII.Washington Irving writes in his book that the Washington family were close friends of Henry VIII.The Washington family was given land for the support of the Divorce of Catherine to Henry VIII arranged by Thomas Cromwell.
Bishop Meade was the religious leader to Thomas Lord Fairfax who hired young George Washington and Christopher Gist as surveyors for the Forks of the Ohio area which is now called Pittsburgh. Christopher Gist grandmother was Edith Cromwell.What's interesting is the Cortez family and name come into the picture with the Randolphs, Bollings and Blairs.Some people believe Bolling is another spelling to Boleyn. There is also some spotty records that Pocahontas was related to Cortez as well as the Randolphs Bollings and Blairs.