This is what I have but it may not be 100% accurate. Please use it as a source for leads. Much of the research was sent to me by very good Weatherford researchers, Bev Allen, Gayle P. and Bonnie Rapert.
Descendants of Thomas Whitheford
GEN 1. THOMAS WHITHEFORD was born Abt. 1585 in Tansworth, Warwickshire, England. He married MARGARET WARING 30 June 1609 in Tansworth, Warwickshire, England. She was born Abt. 1588 in Tansworth, Warwickshire, England.
GEN 2 Their son, JOHN WHITHEFORD, b. Abt. 1615, Tansworth, Warwickshire, England; d. 1706. m. unknown.
GEN 3 Their son, WILLIAM WHITHEFORD, b. 1645, Williamsburg, York Co., Virginia; d. 1732.
GEN 4. Their first born, RICHARD WEATHERFORD, b. Abt. 1674, James City County, VA; d. Abt. 1756, Lunenburg Co., VA. (I descend from his brother, William, b. abt 1678 VA).
GEN 5 His second son, CHARLES WEATHERFORD, b. 1705, Mecklenberg Co., VAm. MARY CORNET/CUPBOARD
GEN 6 Their son MARTIN WEATHERFORD, b. 1726, James City County, VA; d. March 1805, Harbour Island, Eleuthera, Bahamas. He married (1) JANE 1747 in Virginia. She was born 1731 in VA. He married (2) ISABELLA 1775 in GA.
MARTIN and JANE WEATHERFORD had CHARLES, b. 1752 Lunenburg Co., VA
GEN 7 CHARLES WEATHERFORD married SEHOY III 1780 in Creek Nation, daughter of A TOOKABATCHA CHIEF. She was born Abt. 1759 in Taskigi (Old Fort Toulouse nr. Montgomery, Alabama, and died Abt. 1811 in Baldwin Co., Alabama. His occupation: Indian Trader
CHARLES(7) WEATHERFORD (MARTIN6, CHARLES5, RICHARD4, WILLIAM3 WHITHEFORD, JOHN2, THOMAS1) was born 1752 in Lunenburg Co., VA. He married SEHOY III 1780 in Creek Nation, daughter of A TOOKABATCHA CHIEF. She was born Abt. 1759 in Taskigi (Old Fort Toulouse nr. Montgomery, Alabama, and died Abt. 1811 in Baldwin Co., Alabama. His occupation: Indian Trader
5 Children of CHARLES WEATHERFORD and SEHOY are:
-i. WILLIAM "Red EAGLE" WEATHERFORD.d b. 1781 Al;
...1st-Mary Moniac about 1797 in AL;
...2nd-Sopathe Thlanie about 1804 (some accounts say 1813-14) in AL;
...3rd-Mary Stiggins abt 1817 in AL; d. Mar 24,1824, following a bear hunt and is buried next to his mother Sehoy III in a grave in Baldwin Co., AL
Children of Wm Weatherford & Mary Stiggins (b.1783 in AL, d.1832 Mount Pleasant, Monroe Co., AL; buried with other Stiggins at the Baptist Church, Little River; her wooden marker was destroyed in a brush fire. d/o Joseph Stiggins, an Englishman, and Nancy Grey, a Natchez, niece of Chinnabbee):
-->1 Alexander McGillivray Weatherford, b. 1820 who married 1st-Martha Powell. Their children are: Martha E. Weatherford (m. Eli King), Mary Ellen Weatherford (m. Alexander Moniac Sizemore), Percy W. Weatherford, Susan Arelia Weatherford, Frederick Tyler Weatherford, Levetia Weatherford, Charles A. Weatherford.
-->2 Mary Levitia Weatherford. Married Dr. William Forbes Howell, m. April 11, 1842. Monroe Co. AL
-->3 Major Weatherford, who was killed as a child
-->4 John Weatherford, died as a child.
*See: William Weatherford and his wives Mary Moniac, Sopathe Thlanie, and Mary Stiggins by Carol Middleton
-ii. ELIZABETH ("BETSY" ?) WEATHERFORD.
-iii. JOHN "JACK" D. WEATHERFORD, m ELIZABETH E. WALKER on June 9, 1854 n
-iv. ROSSANNAH WEATHERFORD m CAPT. J.W. SHOMO
-v. Un-named daughter, married Alexander Sizemore
(According to the Draper Papers, there was a Charles Weatherford who made a will in Jackson County, Georgia in 1814, leaving a wife, Charity, as well as children named Archibald, Rhoda, Patsey, Betsy, and Susie.- Bonnie Rapert)
More info on the website. I welcome corrections and additions.
Good luck with your research.