I have relatives which would link to yours: my Josef Weil was born Frankfurt/Main and in 1873 he was aged 35, when moving to Mannheim with his widowed mother Regina and brother Adolf (37, born Frankfurt), sisters Mina (30, born Mannheim) and Elise (26, born Landau). Their late father was Simon Weil. Regina was born in Ellerstadt 1806 and died 1883, probably in Mannheim. I suppose this daughter of Josef which you mention - Regina - was born after the death of her grandmother in 1883 and named after her. Mina got married to B.Flegenheimer in Mannheim. I have more about Regina's family, but possibly also her husband Simon Weil was part of the same family.