The folks you call Cullens were actually Culloms. Mark Cullom, Sr. was a ship's master who married Mary Abington, daughter of Lydia Brooke and Lawrence Abington. Lydia was daughter of Henry Brooke, step father of David Wickliffe. Mark's children were Mark, Jr., Mary Butler, and Elizabeth Wickliffe. Mark, Sr., Mark, Jr., Elizabeth, and Isaac al died within 18 months.As far as I have read, all their land was obtained at cut rate prices by Augustine Washington, father of George. The property is now part of the George Washington Birthplace National Monument. Was there a plague, or something more sinister?