I show a Nancy Woodfin who died approximately 1843 as the wife of Ephraim Maxey (approx. 1772-1825).Ephraim's death date is 18 years earlier than Nancy's estimated death date.Could your Dr. Hughes have been Nancy's second husband?
I show Nancy's parents as Rev. Samuel Woodfin and Obedience Gaithright, but your post said they were the grandparents of the Nancy you are researching.Does one of us have incorrect information, or maybe your Elisha Woodfin named his daughter after his sister?Do you think we are dealing with the same Nancy or an aunt and niece?
In any case I would love to exchange information.I have very little to offer on this line.Samuel and Obedience are as far back as I have found.But I could tell you some about the Maxey descendants of Ephraim and Nancy if you like.