Since this surname likely comes from the Middle East and also parts of the fromer Russian Empire, it woud have been pronounced something like "YOU-soo-fee" or maybe "you-SOO-fee", but the basic ancient root of the word is YUSUF or JUSUF meaning "Joseph" in English. Slavic speakers might say Yosip/Josip or perhaps take a surname of Yusupoff/Jusupov, etc. One Russian noble family included Prince Yusupoff, who was the one who killed the peasant-priest Grigory Rasputin.
Look up all the other variations of this name on this and other forums.
All have the same idea of 'descended from the line of Joseph'. This is a very old name going back thousands of years.