| Name | Sex | Birth date | Birth location | Death date | Death location | Spouse | Marriage date | Marriage location |
| Skinner, William | Male | 1591 | Of Hereford, Worc, Eng | | | Style, Mary | Abt. 1621 | |
| Slingsby, John | Male | | | | | Calverley, Isabel | | |
| Smallridge, Richard | Male | Abt. 1560 | | | | | | |
| Smallridge, Thomasyne | Female | | | | | Taylor, Robert | 1616 | Spreyton, Devon, England |
| Smarte, ??? | Male | | | | | White, Joan | | |
| Smead, Whitstill | Female | | | | | Warner, Ebenezer | | Deerfield, Franklin, Massachusetts |
| Smedley, John | Male | | | | | Wheeler, Sarah | May 15, 1669 | |
| Smith, ??? | Male | | | | | Sheldon, Lydia | | |
| Smith, ??? | Male | | | | | Parkhurst, ??? | | |
| Smith, Alice | Female | | | | | Langley, Swithin | June 15, 1601 | |
| Smith, Alice | Female | 1565 | | | | | | |
| Smith, Ambrose | Male | Abt. 1561 | Withcock, Leicester, England | | | Cecil, Margaret | | |
| Smith, Ann Frances | Female | Abt. 1554 | London, London, England | | | Harper, John | December 26, 1588 | London, London, England |
| Smith, Anna | Female | Abt. 1791 | | | Southhold, Gore, Canada | Suydam, Humphrey | | |
| Smith, Benjamin | Male | | | | | Loomis, Ruth | April 11, 1678 | Farmington, Hartford, Connecticut |
| Smith, Darsha | Female | 1737 | TN | | | Ryan, William | | |
| Smith, Dinnah | Female | Abt. 1800 | Sullivan, Tennessee | | | | | |
| Smith, Dorothy | Female | 1636 | Norwich, Norfolk, England | 1706 | Farmington, Hartford, CT | Moore, Isaac | | |
| Smith, Dorothy | Female | 1666 | Northampton, Hampshire, MA | 1740 | Northampton, Hampshire, Massachusetts | Hooker, William | May 30, 1687 | |
| Smith, Ebenezer | Male | 1668 | Northampton, Hampshire, MA | September 15, 1728 | Suffield, Hartford, Connecticut | Barlow, Sarah | | |
| Smith, Ebenezer | Male | December 06, 1702 | Northampton, Hampshire, MA | | | Nelson, Mary | Bet. February 27, 1721/22 - February 1722/23 | Suffield, Hartford, Connecticut |
| Smith, Edward | Male | June 01, 1654 | Bradford, Essex, Mass. | November 01, 1683 | Rowley, Essex, Mass. | Allen, Sarah | | Bradford, Essex, Mass. |
| Smith, Elizabeth | Female | | | | | Smith, James | October 26, 1698 | Hadley, Franklin, Massachusetts |
| Smith, Elizabeth | Female | | | | | Spencer, Eliphalet | March 02, 1757 | |
| Smith, Elizabeth | Female | | | | | Bryan, William | 1744 | |
| Smith, Elizabeth | Female | | | | | Kellog, Nathaniel | October 29, 1765 | |
| Smith, Elizabeth | Female | August 25, 1648 | Of, Wethersfield, Hartford, CT | | Died Young | Smith, Samuel | | |
| Smith, Elizabeth | Female | 1733 | TN | | | Shoemaker, John | | |
| Smith, Elizabeth Frances | Female | 1794 | Sullivan Co., TN | | | Parker, Joseph F. | | |
| Smith, Experience | Female | | | | | Kent, Cephas | 1745 | |
| Smith, Experience | Female | November 09, 1700 | Northampton, Hampshire, MA | | | | | |
| Smith, George Thomas | Male | May 09, 1741 | Buckingham Co., VA | March 20, 1834 | Lexington, Fayette, Kentucky | Agee, Lear | Abt. 1786 | Buckingham, Virginia |
| Smith, Hannah | Female | Bet. January 24, 1645/46 - January 1646/47 | Rowley, Essex, Massachusetts | | | Trumble, Joseph | May 06, 1669 | Rowley, Rowley, Essex, Mass. |
| Smith, Henry | Male | | | | | Pynchon, Ann | 1639 | Dorchester, England |
| Smith, Henry | Male | | Norwich, Norfolk, England | August 09, 1648 | Glastonbury, Hartford, CT | Cotten, Dorothy | Abt. 1623 | Wethersfield, Hartford, CT |
| Smith, Hugh | Male | 1614 | England | September 19, 1655 | Rowley, Essex, MA | ???, Mary | Abt. 1639 | Rowley, Essex, MA |
| Smith, Ichabod | Male | Bet. January 24, 1668/69 - January 1669/70 | Northampton, Hampshire, MA | July 12, 1744 | Northampton, Hampshire, MA | Hurley, Mary | | |
| Smith, Isaac | Male | | | | | Davis, Martha | 1750 | Rutland, Worcester, Mass. |
| Smith, James | Male | | | | | Winchell, Mary | July 26, 1732 | Suffield, Hartford, CT |
| Smith, James | Male | June 12, 1675 | Northampton, Hampshire, MA | | | Smith, Elizabeth | October 26, 1698 | Hadley, Franklin, Massachusetts |
| Smith, James | Male | 1743 | PA | | | Morrison, Janet | | |
| Smith, James Agee | Male | December 06, 1787 | Sullivan Co., TN | December 20, 1875 | Ryarreah, Kane, UT | Love, Margaret | May 24, 1810 | |
| Smith, Joanna | Female | December 25, 1641 | Wethersfield, Hartford, Connecticut | December 28, 1664 | Hadley, Hampshire, Massassachusetts | Russell, Philip | Bet. February 04, 1662/63 - February 1663/64 | |
| Smith, John | Male | | | | | Carter, Abigail | May 07, 1674 | Woburn, Middlesex, Massachusetts |
| Smith, John | Male | | | | | Parkhurst, Deborah | June 10, 1643 | Watertown, Middlesex, Massachusetts |
| Smith, John | Male | 1539 | Of Chelsworth, Suffolk, England | | | ??? | Abt. 1568 | Bocking, Essex, England |
| Smith, John | Male | 1637 | Rowley, Essex, Mass. | July 19, 1661 | Bradford, Essex, Mass. | Parrott, Faith | Bet. February 24, 1655/56 - February 1656/57 | Bradford, Essex, Mass. |
| Smith, Jonathan | Male | | | | | Kellogg, Abigail | November 14, 1688 | Hadley, Hampshire, MA |
| Smith, Jonathan | Male | 1656 | Bradford, Essex, Mass. | 1659 | Bradford, Essex, Mass. | | | |
| Smith, Joseph | Male | | | | | Loomis, Sarah | | |