| Name | Birth date | Birth location | Marriage date | Death date | Death location |
|---|
| John Middleton | May 16, 1848 | | | March 17, 1865 | |
| John Adams Middleton | November 05, 1844 | Elkhart, Indiana | | August 04, 1916 | Mt. Moriah, Missouri |
| John Arthur Middleton | September 14, 1925 | | | | |
| John Downing Middleton | May 04, 1811 | Franklin, Ohio | March 13, 1833 | September 19, 1887 | Parkston, South Dakota |
| John Nelson Middleton | November 1847 | Elkhart County, Indiana | | | in Civil War |
| John Solomon Middleton | November 11, 1833 | Hog Creek, LaPorte County, Indiana | January 04, 1858 | | |
| John Wesley Middleton | October 02, 1835 | | April 18, 1869 | March 31, 1923 | Warren, Indiana |
| John Wesley Middleton | March 09, 1860 | | December 23, 1879 | | |
| Jonathan Downing Middleton | May 15, 1807 | Franklin County, Ohio | February 21, 1828 | January 25, 1853 | Elkhart County, Indiana |
| Joseph Middleton | | | | | |
| Joseph Bigelow Middleton | August 20, 1820 | Franklin County, Ohio | May 11, 1845 | October 10, 1894 | buried in Lowry-Snyder Cem in Mercer, Missouri |
| Joseph Bigelow Middleton | June 15, 1839 | Elkhart, Indiana | | September 07, 1925 | Freewater, Oregon |
| Kimberly Middleton | | | | | |
| Kristine Joan Middleton | January 02, 1964 | | | | |
| Laura Olive Middleton | | | | | died in infancy |
| Lawrence A. Middleton | June 04, 1917 | | | | |
| Leary Albert Middleton | August 22, 1855 | | | October 28, 1855 | |
| Leith Izola Middleton | March 06, 1909 | Atchison, Kansas | May 15, 1926 | October 09, 1933 | Menlo, Iowa |
| Lena Middleton | January 20, 1871 | | September 18, 1890 | | |
| Leona May Middleton | January 01, 1877 | Stuart, Iowa | March 27, 1902 | July 09, 1968 | Greenfield, Iowa |
| LeRoy Swarmstead Middleton | October 20, 1850 | Indiana | October 19, 1876 | | |
| Leslie Reid Middleton | September 03, 1924 | | | | |
| Lester Claudine Middleton | August 19, 1921 | | | August 25, 1921 | |
| Linda Middleton | | | | | |
| Lois Catholeen Middleton | August 19, 1921 | | | | |
| Lois Jean Middleton | | | | | |
| Lola Middleton | | | | | |
| Loquillas Middleton | 1859 | Wisconsin | | | |
| Loquillas Arthur Middleton | 1892 | | | November 16, 1931 | Ottumwa, Iowa |
| Louisa Ann Middleton | March 10, 1842 | Stillwell, LaPorte County, Indiana | October 04, 1875 | January 24, 1932 | buried in Plymouth, Indiana |
| Lovina Middleton | July 18, 1860 | | January 06, 1878 | May 13, 1900 | |
| Lovina Elizabeth Middleton | April 01, 1847 | near Elkhart, Indiana | September 19, 1869 | | Kansas |
| Lucy Middleton | | | January 19, 1905 | August 09, 1907 | |
| Lulu Middleton | | | | | |
| Lydia Lorena Middleton | July 17, 1869 | | February 09, 1899 | | |
| Mae Ethelyn Middleton | November 27, 1900 | | January 28, 1928 | | |
| Mahala Jane Middleton | February 14, 1842 | Elkhart, Indiana | June 17, 1871 | June 1872 | Milltown, South Dakota |
| Margaret Jame (Jennie) Middleton | May 22, 1873 | | 1899 | | |
| Margaret Priscilla Middleton | September 04, 1845 | | June 05, 1912 | | |
| Marilyn Louise Middleton | August 27, 1932 | | July 08, 1951 | | |
| Mark Allen (Gordon) Middleton | April 10, 1954 | | | | |
| Martha A. Middleton | March 03, 1858 | Elkhart County, Indiana | March 12, 1878 | May 08, 1926 | Stockton, California buried at Elkhart, Indiana |
| Mary Middleton | October 25, 1805 | Franklin Co, Ohio | March 16, 1827 | 1890 | |
| Mary Alice Middleton | July 19, 1853 | Schuyler County, Missouri | December 24, 1874 | February 09, 1932 | buried in Ozark Memorial Park, Joplin, Missouri |
| Mary Ann Middleton | | | | | |
| Mary Ann Middleton | | | | | |
| Mary E. Middleton | April 13, 1854 | | 1870 | September 10, 1919 | |
| Mary Elizabeth Middleton | March 26, 1868 | | August 23, 1900 | | |
| Mary Elizabeth Middleton | June 19, 1882 | Glenwood, Missouri | January 23, 1929 | | |
| Mary Ellen Middleton | September 20, 1841 | | November 04, 1866 | September 23, 1906 | buried at Colorado Springs, Colorado |
