| Name | Birth date | Birth location | Marriage date | Death date | Death location |
|---|
| Mary Ellen Middleton | March 10, 1870 | | | April 22, 1913 | Elkhart, Indiana |
| Mary J Middleton | 1840 | | December 11, 1859 | September 20, 1868 | |
| Mary Polly Middleton | 1785 | | | | |
| Max Leroy Middleton | December 31, 1935 | | | February 09, 1936 | |
| Mero Downing Middleton | January 27, 1874 | | | | |
| Merrill Middleton | | | | | |
| Mildred Middleton | July 04, 1913 | | | | |
| Mildred Ilene Middleton | May 06, 1930 | | | | |
| Miles Monroe Middleton | November 11, 1870 | | | November 12, 1894 | |
| Milo Nul Middleton | February 29, 1872 | | | February 22, 1874 | |
| Myrna Marie Middleton | December 21, 1930 | | | | |
| Nancy Jane Middleton | June 29, 1823 | Franklin County, Ohio | April 10, 1846 | January 18, 1908 | Indiana |
| Nancy Jane Middleton | March 09, 1829 | | June 30, 1849 | | Des Moines, Iowa |
| Nelson Middleton | | | | | |
| Nona Middleton | | | | | |
| Olla-Riley Middleton | | | | | |
| Oral Cortina Middleton | May 20, 1851 | | | February 19, 1909 | Elwood Nebraska |
| Orin Allister Middleton | January 21, 1849 | | | | Elwood Nebraska |
| Otis Verdine Middleton | October 12, 1871 | Stuart, Iowa | January 19, 1899 | October 10, 1921 | Coon Rapids, Iowa |
| Ozias S. Middleton | January 27, 1846 | Elkhart County, Indiana | March 14, 1866 | March 10, 1912 | buried at Unionville, Missouri |
| Ozias S. Middleton | November 07, 1863 | | December 25, 1887 | August 04, 1891 | |
| Phidelia Ann Middleton | | | | | died in infancy |
| Ramona Jene Middleton | May 15, 1927 | | | | |
| Ray Middleton | December 19, 1889 | | | October 04, 1893 | |
| Rebecca Isabel Middleton | April 03 | | November 25, 1899 | March 30, 1911 | Buried at Goshen, Indiana |
| Richard Henry Middleton | December 18, 1899 | | | November 10, 1913 | |
| Robert Middleton | | | | | |
| Robert Earl Middleton | April 02, 1919 | | | | |
| Robert N. Middleton | November 14, 1855 | Schuyler County, Missouri | 1885 | July 1903 | buried at Mancelona, Michigan |
| Robert Upham Middleton | September 17, 1873 | | | May 11, 1879 | |
| Roger Middleton | February 20, 1916 | | | | |
| Ross Middleton | May 05, 1914 | | | | |
| Samuel Mellor Middleton | February 17, 1857 | | | Abt October 1865 | |
| Sarah Middleton | January 18, 1851 | | | June 06, 1893 | |
| Sarah Delcena Middleton | October 01, 1871 | near Queen City, Missouri | | August 01, 1896 | Humeston, Iowa |
| Sarah Howard Middleton | April 28, 1815 | Franklin County, Ohio | December 10, 1838 | March 04, 1899 | Livonia, Missouri |
| Sarah Melissa Middleton | April 02, 1842 | | April 18, 1869 | April 21, 1882 | |
| Scott Allen Middleton | August 01, 1960 | | | | |
| Seymour Sylvester Middleton | July 19, 1848 | Madison, Dane, Wisconsin | January 01, 1871 | January 15, 1940 | Stuart, Iowa |
| Sheltz Sylvester Middleton | February 16, 1913 | Adair, Iowa | February 27, 1932 | | |
| Shirley Jean Middleton | | | | | |
| Sindi Ann Middleton | October 05, 1962 | | | | |
| Sommerset Middleton | December 07, 1780 | Sussex Co., Del | March 06, 1805 | April 23, 1824 | Ohio |
| Thomas Middleton | | | | | died in infancy |
| Thomas Middleton | June 20, 1919 | | | | |
| Tina May Middleton | | | | | was 6 years old at time of death |
| Vallie Elaine Middleton | November 16, 1921 | | | | |
| Vera C. Middleton | March 12, 1900 | | August 29, 1926 | | |
| Walter A. Middleton | January 14, 1891 | | December 10, 1911 | | |
| Wesley Middleton | May 22, 1813 | Franklin County, Ohio | October 31, 1835 | February 11, 1885 | |
