When FTM2010 ( you said you were using 2101, so I'll guess that you really mean 2010 ) "crashes" you WILL see that error message. That is normal. BUT the program should then open. When it does, you should do as the program tells you, to Compact your file.
Lets deal with the crashing / closing issue first.
And enter crash into the Keyword Search and click on Search. This will bring up a list of Knowledge Based articles based on your version of Windows. Please follow the instructions, based on your version of Windows. As you go, please make note of what you see, what you did, any error messages, so that IF that article doesn't resolve this, you can post your findings here and we can go from there.