DESPERATE FOR HELP-O'KEEFE OR BURKE

Sarah Burke b.1839 Ireland,(father-Thomas mother-Julia ?);Married Owen Eugene O'Keefe b.1840 Cork; They had 6 children;Thomas b.1857,Agnes b.1860,Julia b.1864,all in Manchester, England. Andrew,MaryAlice,Isabella born in USA. They lived in Brooklyn, NY. We know Sarah had family in USA. Don't know if Owen had any siblings.
ANYONE KNOW ANY CONNECTIONS IN IRELAND or USA??