Hello. My name is Harry Kleiser, and I'm James Abram Kleiser's great grandson. James married Nancy Brush in 1838; they were divorced about 1868. I can't remember the exact years right now, and I don't have my data handy. Anyway, yes, I have quite a lot of information on both families, including a daughter, Emma, born about 1847. I can send you a lot of stuff and also connect you to a Kleiser family site at MyFamily.com, which contains pictures of all these people, including Nancy Brush.
Both Nancy and James lived in Cloverdale, CA until their deaths, James in Sept, 1906, and Nancy in 1911.