I didn't find them in any of my books but i did some checking on the census. You may have this already but in case you don't:
1850 Knox Co, p. 390a
Lewis Cole, 30, wagoner, NC
Susan, 26, Ky
Mary j., 8
Robert Cobb, 23, laborer
Esom Colman, 21, labroer, Ky
Samuel t. Hubbard, 25, school teacher
Also living in Knox Co. 1850 were:
p. 387a Skelton Coleman, 22, Ky
Susan Coleman, 63, NC
phoebe, 58, Nc
John B., 17, Ky
1860 Boonville, Owsley, p. 338
Lewis Cole, 39, grocery keeper, NC
Nancy E., 6
Margaret Cole, 18, domestic girl
Anderson Bowman, 27, farmer
1870 Boonville, Owsley, p. 322a
Lewis Cole, 51, Hotel Keeper & Jailer, NC
Samuel, 21, dry goods merchant (ret.)
John, 18, clerk in store
Nancy E., 16
Phoebe Coleman, 80, NC
Berry Buford, 70, white, farm labor, ky
william Rose, 20, mulato, farm labor, Ky
1880 Boonville, Owsley, ed 79, p. 302a
Lewis Cole, divorced, 53, Hotel Keeper, NC/VA/NC
Berry Buford, black, 78, servant, Ky/Va/Va
John Cole, single, age at death:75, born in Ky, father: Lewis Cole, mother: Susan Coleman, died on Jan. 14, 1926, buried in Gabbard grave yard on Jan. 15, 1926."
Owsley Co. Death Records 1854-1944 compiled by Robert L. Smith
"Lewis Cole to Susan Coleman about 1848, daughter of Samuel Coleman & Phoebe"
"Lewis Cole to nancy Evans, 4/1877, Nancy a widow. In the Echo 13 Apr 1877."
'James Cole to Malinda Combs, 1/10/1867, in Owsley Co., son of Lewis Cole & Susan Coleman, daughter of Samuel Combs & Nancy Cornett."
Owsley Co. Marriages 1843-1929 compiled by Robert L. Smith
"William Frank Cole b: 2/1865, to Lewis Cole and Susan Coleman."owsley Co. Births 1843-1930, compiled by Robert L. Smiith
Even though Robert Smith's book says that Lewis and Susan were married in Owsley co. I think it is more likely they were married in Knox. My suggestion is that you write to Knox Co. Courthouse and see if they have a record of their marriage.
401 Court Square
barbourville, Ky 40906
Be sure an include a SASE so they can respond easily.
You have Susan's last name as Combs and not Coleman. Unless we are talking about 2 different people I think her name was Coleman. There was a Claiborn Combs who lived in Perry co. which is near Knox so maybe there was a Susan Combs who married a Lewis but I couldn't find any Lewis Coleman living in Perry--just in Knox and Owsley.
Sorry I couldn't help you more.