I'm not related to this family but thought I may be able to help you.The marriage date of 1833 seemed a bit off, if Martha and Mary were born in 1865 in Kentucky; that means James and Margaret were married about 32 years before these daughters were born.It appears from census records, that James and Margaret probably married in Ohio and probably about 1856 or 57.The 1860 census has them in Campbell Co., Kentucky, with children Ida, age 3, b. OH; Lucy, age 2, b. OH; Frank, age 1, b. OH; and two others John Muratt, 21, b. VA, and Phoebe Muratt, 63, b. VA.
The 1870 census has the family in Marion Co., IN, at Indianapolis, apparently moving for James' job as a railroad clerk or agent.In the 1870 census they have children Ida, Lusia (Lucy), Frank R., Martha, Mary, James H., Carrie e., and Alexander P (age 1).Looks like in this census they moved from Ohio to Kentucky, to Ohio, and then to Indiana.
By 1880, the family is back in Jefferson co., KY, living at Louisville, with James still working on the railroad.This census says that the parents of James A. Semple were born in Scotland.He continues to state that he was born in Pennsylvania.According to census records, James A. Semple was born between 1823 and 1829.
By 1900, I find their son, James, married and living in Denver, CO, with wife and children.James (Jr.) named one of his own sons James A. Semple.
I'd look at the 1850 census for Pennsylvania or Ohio to find James A. Semple, and look for a marriage record in Ohio for Margaret to James.