The Revolutionary War brought great hardships to the citizens of Maryland, especially to Prince George’s, Charles, and St. Mary’s County. British warships roamed the Chesapeake and tributary rivers at will, impounding supplies and in many instances looting and sometimes destroying homes, churches and warehouses. The successful conclusion of the war brought detrimental effects to Marylanders. The great demand on supplies, manpower and money created by the war, combined with the curtailment of trade with Britain, led to a profound decline in the economy in the years immediately following the war.Also, many Maryland farms were exhausted from many years of unskillful cultivation methods. In addition, Maryland Catholics through the League of Catholic Families from Prince George’s, Charles, and St. Mary’s County were seeking to migrate to the west to find more religious freedom than found on the eastern seaboard. Counterbalancing these religious and economic facts was the fact that the vast expanse of land west of the Appalachians now became available to citizens brave enough to relocate there. Some of the land was given out in grants to Revolutionary War veterans in payment for their services, and more was available for purchase at low cost. These circumstances resulted in a massive movement of Marylanders to the western lands of Kentucky following the war. For these Marylanders, the usual route to Kentucky started overland to Pittsburgh, then down the Ohio River to Maysville, followed by another overland journey to one of the forts, called "stations", near the area chosen for settlement. Those who chose not to continue their journey to the Kentucky interior or further westward would have in all likelihood settled in Maysville.
I hope that this helps in your understanding of the historical implications of the Maryland migration westward after the Revolutionary War.