I believe William to be the brother of my gggrand dad, Ephriam Sr. I also have him dying in Rulo, NE. I only have the marriage to Nancy (Elizabeth prior to 1850?), I have some trouble with the last name and have added the corrections to Ancestry.com. I also have Issac born in 1853 and William married to Nancy in 1851.
If this all matches, then you also likely know their parents were William (Virginia 1788) and Mary (Ohio 1797).
Do you know more on the parents? I see there are a number of Elshires (Alshires and other spellings) from all around the same area, but I can't seem to fit William in with any of them.