The first George, Lord Baltimore, was secretary to Robert Cecil who was one of the most powerful men in England. Through this connection, George rose to become one the Secretaries of State to King James I. For his service, King James granted George the title of Baron of Baltimore in Ireland and a grant in Newfoundland which he visited. When that didn't work, George visited Virgina looking for a better place. King Charles I granted George what is now Maryland, but George died before he could get there. His eldest son Cecil became the 2nd Lord Baltimore and sent his brother Leonard on the ships Ark and Dove to start the colony in 1634. The only direct descendants of the first George that I am aware of are through Leonard or through Benedict Swingate Calvert who was the fifth Lord Baltimore's illegitimate son who came to Annapolis in the early 1700s and ended up with a daughter, Nelly Calvert, who married George Washington's adopted son and several other children who lived in Prince George's County, Maryland.There is a line in England by another name that I could look up.
I went to England in May, 2002 and visited Kiplin Hall near York which is in the process of being restored with the help of the U of Maryland. Kiplin was the first George's home.