So I discovered some more info last night that definitely seem to support this connection, more circumstantial evidence, but some of it seemingly strong:
1) I found a local history for Texas for Isaac's son who left from Arkansas to Texas, it confirms his parents were from Virginia but unfortunately not the county, but does give his mothers name as Susan C. Roberts.
I found the marriage record for Isaac "Davis" married to Susan Roberts in Charlotte Virginia.The county right next (to the north west) of Mecklenburg, roughly 30 miles or so away (from center to center) and formed from the same Lunenburg county in the late 1700s.
2) Isaac Daws lived in Princeton, Dallas County, Arkansas, on the same census his neighbors include about 15+ "Holmes" that trace back to Mecklenburg County and to the family that intermarried with that Daws family.Isaac's sister and uncle married a Holmes and his probable father's will is witnessed by an Isaac Holmes of that same family.
There are other families living next door from the same Mecklenburg County, including Jones and Dortch families.
3) Isaac first landed in Rutherford Tennessee by the 1830s census.I'm still looking into it but it seems some of the Holmes descended family also were there too.
Not a silver bullet like I was hoping for but it's starting to seem like a pretty crazy coincidence if this isn't the same Isaac Daws since he landed in the same town in the same county as at least 20-30+ people from Mecklenburg and the biggest family "Holmes" intermarried and were heavily tied.
He also was married in the next door county, not sure why it would be that and not Mecklenburg so time for me to learn more about the county histories and where John Daws actually got land grants (I think he got land grants in Lunenberg before it was split to Mecklenburg and Charlotte).