1800-25 in St. Louis, MO, LA, and Cuba

Manuel LISA, Spanish fur trader in St. louis, MO.married ca 1803 Mary Polly CHARLES St. Louis, MO and had four children who apparently died before having children. Manuel married Mitain, an Omaha Indian, and had two childrenChristopher and Rosalie LISA who married ca 1842 Madison ELY in Madison Co., IL. Manuel had a brother, Joaquin Joesop, who Marie Francisca MORO 1794 in New Orleans, LA and possibly moved to Cuba circa 1815. I am interested in this family and its ancestry and descendants.