Re: Nancy Middleton of SC m. Isaac Waddell, had a daughter ca. 1810
As of now, I still don't have any clear indication of Mrs. Nancy/Ann Waddell's parents.I think the most promising candidate for her father is Alexander Mackenzie, (illegitimate?) son of Lady Mary Mackenzie who married, as her fourth husband, Henry Middleton.This would make Nancy a step-niece of Arthur Middleton the Signer and would explain why so many Middleton family names are used among her descendants.
This Alexander Mackenzie is interesting to us because it appears his youngest daughter Euphemia married Robert Goodlet in Scotland and named her only child Ann.That there was a Mrs. Goodlet connected to Martha Waddell Hubbard's family is suggested in the work of Harriet Brownlee Holman, available through the Family History Library.
Alexander Mackenzie's wife was Miss Sarah Mansfield.They had several known children together according to birth and Christening records, including Margaret, Mary, Sarah, Jabez, Hannah, Philip, and the Euphemia mentioned above.Jabez was doubtlessly named after his half-uncle, Lt. Col. Jabez Clarke Mackenzie, Mary Mackenzie's son through her clandestine marriage to Capt. Robert Clarke.Alexander's paternity is unclear to me at this time, but he seems (from the letters of Eliza Lucas Pinckney) to have been of age while his mother was married to Thomas Drayton (who died in 1760), which would indicate he was born long before Mary Mackenzie married Robert Clarke in 1750 and had a different father.
This is confirmed by the 3 May 1786 entail for the lands and estates of Lord Macleod, Mary Mackenzie's brother, in which Jabez Mackenzie is named as the "only son of the Lady Mary Mackenzie, by Clark, Esquire, her first husband."As Alexander is passed over in this entail in favor of Jabez, it seems likely he was his mother's illegitimate son, though the Charleston Morning Post announces the 1786 arrival of "A M'Kenzie Esq; son of Lady Mary Middleton by a former marriage".