There are quite a cluster of Nodwells that lived in Rotherhithe in the Seventeenth Century. The earliest record I have found so far is for the burial of Jonathan Nodwell at St Mary's Church in 1675. Rotherhithe was one of the centres of the London docks, and the home port of the Mayflower whose Captain is also buried at St Mary's. John + Jane and Samuel + Elizabeth Nodwell are recorded as having a number of children there between about 1670 and 1710, and could have been well placed to take part in the migration to Ireland that happened at that time.
Prior to that, in the first half of the seventeenth century, the family seems to have clustered arount Ware and Hertford, about 20 miles north of London.