Re: Isaac H. Pierce b. 1800/01 in MASS.
I have a Sarah Quimby Pierce, born (acc. to her death cert) on 14 Feb 1836 in Louisville Kentucky to Thomas J. Pierce and Martha Quimby.
It indicates that Thomas J. Pierce was born in Louisiana (LA), but two earlier census records indicate Sarah's father was born in Massachusetts.Do you have a Thomas Pierce, perhaps a brother to Isaac, born in MA?Your information that Eleazer's family wasin Louisville KY for a while made me think perhaps there's a connection here.