Several years ago I plotted many of the landmarks mentioned in Spruell wills, deeds etc. Although I was most interested in the landmarks identified in the wills of John Reed Spruill and his brother Samuel Spruill, I did run into several Spruell references. Included among those was a "Spruill's Bluff", "Spruill's Landing", "Spruill's Crossing", and "Spruill's Swamp".
Godfrey Spruill along with Samuel Spruill (father of the two Spruill's mentioned above), owned about 1700 acres largely between the Scuppernong and Bull's Bay, along Albermarle sound. "Spruill's Bluff" overlooked the Bay (I wouldn't have referred to it as a Bluff, but...). "Spruill's landing included a warehouse where a number of community meetings were held. "Spruill's Crossing" was across the Scupernong.
The reference to Spruill's Bay sounds like a reference to the part of the Bay around "Spruill's landing". Although I've never seen the reference, given the amount of land owned by the Spruill's in the area, it wouldn't be an inappropriate description of that part of the Bay owned by the Spruill's.
Most of what I've described is from memory, but hopefully might help make sense of the reference to "Spruill's Bay".